|Object Name||Flask, Carrel|
|Title||Carrel Flask Holder|
|Description||Stainless steel. Three-sided rectangle--the open side is part of a circular well and opening to hold the body of the Carrel flask. Copper flanges screwed on top to hold flask down (flask slips between flanges and lip and bottom).|
|Collection||Wilton Earle Collection|
|Caption||Carrel Flask Holder|
Dr. Wilton Earle pioneered processes for growing cells in culture during the 1930-1950s to study how cells become cancerous. He developed a three-dimensional culture containing multi-layered cellophane sheets or glass helices for growing clones of a single cell. From "Dr. Earle, World Expert on Tissue Culture, Dies. Served NCI Since 1937," NIH Record, June 16, 1964, page 7: "Dr. Earle made many significant contributiions to the development of tissue culture science and technology. His contributions were outstanding in improving tissue culture techniques and in advancing the purposes for which long-term, large-scale cell culture could be used in medical research, specifically in cancer research. He was a pioneer in demonstrating that carcinogenesis occurs in vitro."
Carrel flasks were developed by Alexis Carrel (1873-1944) in 1923. They enabled the growth of cell cultures in medium for weeks or even years. He trained Wilton Earle in these techniques. Earle and his group used extensive photomicrographic techniques and invented this holder to to secure Carrel flasks to the mechanical stages of microscopes for photography. The spring clips are made of phosphor-bronze.
|Number of images||1|
|Organizations||NIH, NCI, Tissue Culture Section|
|NIH Property #||none|
|Old NIH Property #||none|
Earle, Wilton Robinson
Sanford, Katherine H.